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Department
Cell and Systems Biology
Course
CSB428H1
Professor
U.Tepass
Semester
Fall

Description
CSB428H1F Article #2: Chuang et al. SARA and Rhodopsin Transport Introduction OS discs are renewed whereby rhodopsin-laden vesicles in the OS axonemal cytoplasm fuse with nascent discs abundant in PI 3 and FYVE domain protein SARA interacts with PI P, rh3dopsin and syntaxin 3 SNARE to regulate this process. Rhodopsins C tail has an address signal to OS and also binds SARA. FYVE domain is a conserved double zinc finger motif that binds PI P 3pecifically. SARA (smad anchor for receptor activation) has FYVE and is located on EE. SARA interacts with rhodopsin C In yeast two hybrid and GST pull down assay, rhodopsin C interacts with human SARA. Ab for rhodopsin also co-immuniprecipitated endogeno
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