CSB346H1 Study Guide - Final Guide: Raphe Nuclei, Locus Coeruleus, Peripheral Chemoreceptors

• School: UTSG
• Department: Cell and Systems Biology
• Course: CSB346H1
• Professor: Jimmy Fraigne

Document Summary

Surgery on lambs at the level of the vena cava and an extracorporeal gas exchange circuit. If co2 is removed, ventilation decreases to match the co2 production of the lungs. I(cid:374) hu(cid:373)a(cid:374)s, de(cid:272)rease of pco2 (cid:271)(cid:455) h(cid:455)per(cid:448)e(cid:374)tilatio(cid:374) (cid:272)a(cid:374) (cid:272)ause ap(cid:374)ea. Central chemoreceptors are important in monitoring co2 levels in conditions like sleep. Increase of pco2 by inhalation increases respiratory frequency and tidal volume. Carotid bodies and central chemoreceptors compared with just central chemoreceptors in response time. Peripheral chemoreceptors also detect and respond to changes in co2/ph. 3 regions on the ventral surface of the brainstem that responded to focal acidification. Co2 + h2o h2co3 h+ + hco3- How do cells sense ph changes: intrinsic cell membrane property, synaptic transmission, cell ph regulation. Experiment: neuronal depolarization (or hyperpolarization) is produced by hypercapnia. The effect has been attributed to an intrinsic membrane property, perhaps involving a k channel.