CSB351Y1 Study Guide - Final Guide: Ribozyme, Playstation 3, Microrna
Document Summary
Prions: prion gene on short arm of chrm. 20. Prpc: rich in alpha-helices (no beta sheets) ; prpsc: isoform of prpc with rich beta sheets, in unfolding of alpha sheets and refolding of beta sheets, resistant to proteolysis. No immune response for prions (cellular proteins). Prions are not the cause for alzheimer, parkinson"s disease and amyotrophic lateral sclerosis (als). Conformational changes in proteins are common to prions and alzheimer. Inherited> autosomal dominant; ffi- familial fatal insomnia: acquired> gh injection, cornea transplant, medical instrument. Cjd>affect language & memory; early signs> depression, sleep disturbance. Helical, ss 3 rna pieces, polymerase packaged with its rna. Ambisense: s of phlebo, s&m of tospo. Antigenic shift and drift> not as serious as influenza. G1 & g2: receptor binding for animal cells & insect cells (in hanta, one for humans and one for mice). Transmitted by insects and mosquitoes (arthropod vectors) except hantaa virus (transmitted through mice). Hantaa viruses have no known arthropod replication cycle.