CSB428H1 : Article #5 Summary
24 Dec 2010
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Csb428h1f article #5: morais-de-sa et al. apkc phosphorylation of bazooka. baz localizes below par-6/apkc and excluded from apical domain by apkc phosphorylation that disrupts baz/apkc binding, which is also helped by the crb complex. both crb and sdt bind directly to pdz of par-6. Two c" thr of crb are phosphorylated by apkc and is required for crb activity. baz binds arm and de-cad and echinoid of aj. In the absence of apkc phosphorylation, baz recruits aj to apical, and expands lateral domain. In neuroblasts, baz recruits par-6/apkc to the apical cortex and apkc phosphorylation of numb and mira exclude them from apical domain. Scrib, dlg and lgl localize below apical lateral junctions to antagonize crb complex. baz can bind par-6-apkc using cr3 and pdz domains, but is excluded from par-6/apkc domains. Baz is below par-6/apkc in follicular epithelium apkc is apical and baz is more basal with arm and aj.
