CJH332H1 Study Guide - Midterm Guide: Substantia Nigra, Adrenal Medulla, Adrenal Gland
Document Summary
Neurobiology of stress people have different stressors stress (physical or psychological) > brain reacts, body reacts > hpa axis, immune system prolonged, excessive stress > higher levels of glucocorticoids > glucocorticoids affect neurons & synapses. Acute stress, chronic stress, physical stress, psychosocial stress. Immobilize animal [physical] in bag > stress > +acth > +glucocorticoids. Social defeat [psychosocial] larger animal with smaller animal > stress for smaller. = neurological change + anatomical change + behavioural change. Stress affects many neurons, affects neurons differently in different parts of the brain amygdala spiny neurons emotional regulation. Ca3 pyramidal neurons mpfc pyramidal neurons executive functions integrate +ve & -ve stimuli arousal & reward, motivation reward seeking, learning context information in memory memory dysfunction in trauma hypervigilance/hyperarousal hyperarousal, anxiety, addiction diminished interest social avoidance deficient attention directing. +stress > +glucocorticoid release > binding to receptors can block glucocorticoid receptor using blocker ru-486. > increase in vesicle fusion and glutamate release (in the pfc and fc)
