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Study Guide

[HMB265H1] - Final Exam Guide - Everything you need to know! (112 pages long)


Department
Human Biology
Course Code
HMB265H1
Professor
Maria Papaconstantinou
Study Guide
Final

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UTSG
HMB265H1
FINAL EXAM
STUDY GUIDE

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Chapter 1
Homework:
Introduction to the course
Importance of genetics
Goals of the course
Lecture Notes: Genetics - The Science of Inheritance
Many common and rare diseases are inherited
Genetics can help develop new treatments for these conditions
Infectious diseases have a genetic component (AIDS, malaria resistance, etc)
Genetics and Medicine - Why you Should Care
Over past 30 years - scientists have been trying to find genes and relate them to chars
Genome-Wide studies, published publically
Map of Human Traits
15 years ago - human genetic code published
Bacteria have been using it to get rid of specific bad DNA
Recently harnessed by scientists to help edit the genome of disease
CRISPR - new technology in genetics, seen later in the course
Genomics Revolution
New Treatments: Genes to help efforts to cure
Diagnosis and prediction: Will your child have the disease?
Gene therapy: Replacement of "diseased" gene with "normal gene"
Pharmacogenomics: How genetics affects drug impact
Ultimate Goals of Medical Genetics
They help in assessing risk, rec'ing tests, interpreting results
Drug Predictions and Genetic Counselling
How should probability results be interpreted?
Should we test for diseases with no cure?
Canada: There is no law against discriminating against genetics
US: 2008 - employers and insurance can't discriminate on genetics
Gene companies can keep information up to 10 years
Privacy (employers and insurance are affected)
Gene therapy: what is normal and what is a disorder?
Ethical Concerns about Medical Genetics
2013: DNA can't be patented as per US law
Patenting Genes
All notes posted online, no fill-ins
Textbook: Genetics: From Genes to Genomes, 1st Cdn Ed
Req readings on lecture handouts
Tutorials start Sept 19
No use of anything there, only non-prog calc
Emphasis on tutorials and problem sets for them
Lecture Review Sections: T, 1610-17 CH
Review Sessions: F 1510-17 (locations on portal per week)
Course is focused on problem solving as opposed to
knowledge
Pre-Lecture Notes:
Lecture 1: Sept. 13, 2016
September 13, 2016
3:00 PM
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2013: DNA can't be patented as per US law
Crop and livestock improvement rely on understanding genetics
Genetic engineering is becoming very widespread
Genetic diversity of crops & livestock affects long-term survival
Genetics and Agriculture - Why you Should Care
Habitat destruction reduces genetic diversity
Genetic diversity affects a species' ability to adapt to change
Low genetic diversity also increases exposure of populations to genetic disease
Genetics and Conservation - Why you Should Care
Genetics helps us understand the way organisms work, how they develop, how they behave,
and how they adapt to their environment
Progression: DNA --> Protein --> Organismal Traits
Genetics and Biology - Why you Should Care
Researchers have identified genes that influence risk of diabetes
But most only shows a small increase in risk, not whole variation
Diet and lifestyle plays a more important factor here
Some are purely genetics, others are purely environmental
There's a spectrum of disease where some are more influenced by genetics than others
Genetics of Type 2 Diabetes
To better understand genotypes and phenotypes
To understand how genetics is used to understand biology
To understand how predictive genetics is
To understand what Genetics can tell us about dev and evo of organisms
To understand how all this is discovered
Aim of HMB265
End of Lecture.
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