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Study notes for lecture 01

2 Pages
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Department
Human Biology
Course Code
HMB265H1
Professor
Stephen Wright

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Lecture 01: Genetics and genomics of human
biology
What is genetics?
-Science of inheritance
-Queries
oWhat is inherited?
oHow is it inherited?
oWhere does heritable variation come from?
oHow do heritable traits change over time?
Why is genetics impor tant?
-Medicine
oInheritable diseases, contagious diseases with genetic
component
Variation in DNA influence variation in traits
mapped on chromosomes, thus chances of
getting the condition
oUnderstanding disease’s genetic basis/cause for
treatment and screening
oUltimately, medical genetics
Develop treatment/cure if disease genes known
Diagnose presymptomatic disease, and predict
child’s likelihood of getting it
Develop gene therapy (rep lacing diseased gene
with normal)
Understand how genetic makeup affect drug
response
-Agriculture
oCrop and livestock improvement
oGenetic diversity affects long-term survival of crops and
livestock
oGenetic engineering increasingly common
-Conservation
oHabitat destruction reduces genetic diversity
oGenetic diversity affects ability to adapt to changing
environments
oLow genetic diversity increases exposure to genetic
disease
-Biology
oDNA encodes proteins, which affect traits
oUnderstanding organism develo p me nt, behaviour,
adapting
oGenes cannot determine personality
Beyond nature vs. nurture
-Ex. type II diabetes
oNumerous genes identified to increase risk minimally
oDiet and lifestyle have major impact
-Continuum degree of genetic v. environ mental influence
How do we know what we know?
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Description
Lecture 01: Genetics and genomics of human biology What is genetics? - Science of inheritance - Queries o What is inherited? o How is it inherited? o Where does heritable variation come from? o How do heritable traits change over time? Why is genetics important? - Medicine o Inheritable diseases, contagious diseases with genetic component Variation in DNA influence variation in traits mapped on chromosomes, thus chances of getting the condition o Understanding diseases genetic basiscause for treatment and screening o Ultimately, medical genetics Develop treatmentcure if disease genes known Diagnose presymptomatic disease, and predict childs likelihood of getting it Develop gene therapy (replacing diseased gene with normal) Understand h
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