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Study notes for lecture 7

3 Pages
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Department
Human Biology
Course Code
HMB265H1
Professor
Stephen Wright

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Lecture 07: Sex-linked traits and chromosomal
theory of inheritance
Dihybrid cross predictions
-Linked assortment: traits segregate together in progeny
-V. independent assortment: traits segregate independently
Linkage effects
-2 linked genes
oEx. cross square-red and round-green
F1 square-green
F2
Chromosome theory of Mendelian inheritance
-T. Boveri and W. Sutton
-n: haploid number
o In humans, n = 23
2n = 46
-Homologous chromosomes
oHomologous metacentric chromosomes:
oHomologous acrocentric chromosomes:
oCentromere:
oSister chromatids:
oNonsister chromatids:
-The postulates
oFertilized eggs receive only gametes
oGametes contain hereditary information
oSperm and eggs contain one copy of 1n
chromosomes
V. non-sex cells contain 2n
Meiosis
oFertilized egg’s chromosomes consist of one
maternal copy and one paternal copy
Mendels law of segregation
oDuring meiosis, each chromosome pair goes to
opposite poles independently
Mendels law of segregation and of
independent assortment
-Chromosomes behave like genes
Testing the chromosome theory
-Evidence from sex chromosomes
oCross XX and XY
F1 male and female in 1:1
Fertilization
oHereditary information determining sex located on
chromosomes
Other traits similarly determined
Sex-linked inheritance
-Cross red and white
oF1 red
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Description
Lecture 07: Sex-linked traits and chromosomal theory of inheritance Dihybrid cross predictions - Linked assortment: traits segregate together in progeny - V. independent assortment: traits segregate independently Linkage effects - 2 linked genes o Ex. cross square-red and round-green F1 square-green F2 Chromosome theory of Mendelian inheritance - T. Boveri and W. Sutton - n: haploid number o In humans, n = 23 2n = 46 - Homologous chromosomes o Homologous metacentric chromosomes: o Homologous acrocentric chromosomes: o Centromere: o Sister chromatids: o Nonsister chromatids: - The postulates o Fertilized eggs receive only gametes o Gametes contain hereditary information o Sperm and eggs contain one copy of 1n
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