HMB300H1 Final: HMB300 Lectures (6-11) & Summary
Document Summary
Improved cognition, protection from neurodegeneration (maybe), protection from mood disorders (perhaps) Four biotypes of those who may benefit from therapeutic intervention for depression. Not everyone responds to medications used to treat depression i. e. ssris: monoamine hypothesis of depression monoamine levels fall in depression (nts alone cannot explain) Nts and physical changes to brain: smaller gray matter in some areas, larger gray matter in other areas white matter changes, reduced hippocampal volume, cell death, cell loss. Previously thought that brain could not have neurogenesis, brain in skull, already little space. Ionizing radiation high doses of ionizing radiation, white band of fur on top of skull, protected other regions with lead shield. Subject subgranular zone (sgz) of dentate gyrus of hippocampus irradiated with ionizing radiation. Results even though adult animals thought to have no proliferating cells, radiation of sgz caused deficits in behaviours.