Welcome to HMB265H1F General and Human Genetics
Detailed Syllabus 2013-2014 Fall Session
Course Coordinator: Dr. Maria Papaconstantinou, Human Biology Program
Course Instructors: Dr. Stephen Wright, Ecology & Evolutionary Biology (Lectures 1-11)
Dr. Belinda Chang, Ecology & Evolutionary Biology and Cell & Systems
Biology (Lectures 12-22)
Lectures: Tuesdays 3:10 to 5:00 pm* and Fridays 1:10 to 2:00 pm, Convocation Hall
*Lecture Review Session/Office Hours: Tuesdays 4:10 to 5:00 pm, Convocation Hall
*Midterm Exam—Tuesday, October 22 from 3:10 to 4:20 pm
Arts & Science Calendar Course Overview [24L, 12T]: An introduction to classical and modern
methods of genetic analysis. Topics include Mendelian genetics, the genetics of human population
and disease, genomics, and applications of genetics to human society.
Exclusion: BIO260H1, BIO207H5
Course Description: An understanding of genetics is essential for all life science students, and is
becoming increasinglyimportant for all members of society. This course is designed to give you a
solid grounding in genetics. Topics include Mendelian genetics, the genetics of human population
and disease, genomics, and applications of genetics to human society. A variety of activities—
lectures, readings, mandatory tutorial quizzes, and assignments—are planned to help you learn the
material. To do well in the course, we recommend that you participate fully in all of these activities
and that you keep up to date with the material. We hope you enjoy the course.
Lecture notes will be posted under Course Documents before the lecture, please bring a printed
copy to class. Make sure you have a copy of the lecture notes in your possession well before
quizzes, the midterm test and the exam in the event of a problem accessing the course website.
If you have questions regarding the course material, please post them on the Discussion Board
section of the course website. We encourage students to answer questions too—this is a great way
to make sure you understand the material.
For questions of an administrative nature unrelated to course content, please post on the Discussion
Board section of the course website under “administrative questions”, or contact Dr. Maria
Papaconstantinou via the course administrative email: [email protected]
Required textbook and solutions manual (available as a bundled package, U of T bookstore):
1. Griffiths AJ, Wessler SR, Carroll SB and Doebley J (2011) Introduction to Genetic Analysis,
10th edition, W.H. Freeman and Company, New York.
2. Scott, D, Sia, EA, Brockett, M, Fixsen WD and Lavett DK (2011) Solutions Manual for
Introduction to Genetic Analysis, 10th edition. W.H. Freeman and Company, New York Optional Material:
GeneticsPortal® for Griffiths' Introduction to Genetic Analysis, Tenth Edition, is a learning
environment that integrates an interactive eBook, animations, and communication tools, as well as
practice quizzes, tests, and assignments. If you have purchased either a package from the U of T
bookstore with the GeneticsPortal Access Card or the Access Card itself, please follow the
instructions posted under Syllabus on the Blackboard course site to register your activation code.
HMB265 Lecture Schedule:
Date Lecture Topic Textbook
Sep 10 1 The genetics & genomics of human biology 1
Sep 13 2 Mendelian genetics for single gene traits 2, 3
Sep 17 3 Molecular basis of genetic polymorphisms and their 2
Sep 20 4 Pedigree analysis 2
Sep 24 5 Extensions of Mendelian genetics I – dominance, co- 6
dominance, penetrance, expressivity
Sep 27 6 Extensions of Mendelian genetics II – 6
Oct 1** 7 Sex-linked traits & chromosomal theory of inheritance2, 3
Oct 4** 8 Linkage & recombination 3, 4
Oct 8 9 Linkage mapping 4
Oct 11 10 Population genetics 18
Oct 15 11 Genomics 14
Oct 18 12 Quantitative genetics 3, 19
Oct 22 Midterm exam
Oct 25 13 Quantitative trait loci 19
Oct 29 14 Genetic mapping & complex traits 18, 19
Nov 1 15 Mutation 16
Nov 5 16 Transposable elements 15
Nov 8** 17 Large-scale chromosomal changes I 17
Nov 12** November break-no classes
Nov 15 No classes due to Fall Convocation
Nov 19 18 Large-scale chromosomal changes II 17
Nov 22 19 Epigenetics 12
Nov 26 20 Using genetics to understand development 13
Nov 29 21 Genetics of cancer 16
Dec 3 22 Gene therapy 15
*Required pages will be posted in the lecture notes.
**Lectures given by Dr. Maria Papaconstantinou Evaluation:
Term Mark (55%) 25% Midterm exam (Oct.22)
20% Tutorials (weekly)
10% Assignment (Nov.4)
Final Exam (45%) (Final exam period)
Exams: 90-95% of the questions are multiple choice, with the remainder short answer questions.
Location: TBA. If you miss the exam for a valid reason, within one week drop off the appropriate
documentation (see below) in the Human Biology Office.
Content: all lectures and tutorials.
During the Faculty of Arts and Science examination period.
Tutorials (Mondays weekly, starting Sep.16):
The tutorials follow a team-based learning format. All tutorials start with a short individual quiz
(2/3 tutorial mark). See below for the pre-tutorial readings and problems for each tutorial. This is
the information that will form the basis of the quizzes. All the quizzes will be a combination of
multiple choice and short-answer questions. Students then discuss the reading/problems and
answers in small groups. Each group hands in one set of answers to the quiz based on their
discussion (1/3 tutorial mark) before presenting to the tutorial group. Please attend the tutorial that
was assigned to you. If you are not on the class list for that tutorial, you will not be allowed to stay
in the tutorial. If you miss a tutorial for a valid reason, within one week drop off the appropriate
documentation (see below) in the Human Biology Office.
Tutorial Schedule of Assigned Readings, Problems, etc. (to be completed before tutorial):
Date Number Assignment
Sep No tutorial
Sep 1 Chapter 2 Problems: 42, 46, and 48
16 Chapter 3 Problems: 25, 28, 46, and 48
Sep 2 Chapter 2 Problems: 44, 45 (see Unpacking Problem 45 below the problem),