IMM250H1 Study Guide - Final Guide: Endosome, Tap1, Antigen Processing

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3 Feb 2013
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Antigen Processing and Presentation
MHC antigen presentation
Antigen processing in a nutshell
Proteins from pathogens are cleaved into peptides
Peptides are inserted into MHC groove
MHC presents peptide to naive T cells
T cells mature and start immune response
T cells only recognize antigens that are...
o Peptide antigens
o Linear epitopes
o Cell surface antigens in self MHC
Proteasomes
4 rings of protein sub-units form a cylinder
Ubiquinated proteins go inside smaller peptides come out
During immune response:
IFN (interferon) γ induces LMP2 + LMP7 (genes located in MHC) + MECL-1 to be added
Preferentially generate 6-12 aa peptides w/ hydrophobic C-terminal or basic resides
o MHC Class I compatible
TAP proteins = Transporters associated with Antigen Processing
TAP-1 & TAP-2 = genes in MHC induced by IFN-γ
Sit in RER membrane and import peptides made by protesomes from cytosol
Preferentially transports peptides 8 aa or longer w/ hydrophobic or basic C-terminal ends
MHC Class I compatible
Adjuvants ... the immunologist’s dirty little secret...
In order to induce an immune response, protein antigens must be mixed with adjuvant
A mix of bacterial products that activate innate responses
Initiate the 2nd signal (cytokines or inflammatory innate responses)
w/out strong 2nd signal, you wont gain immunity
ex// oil proteins have a harder time diffusing out of the vaccine get repeated infection
Antigen Presenting Cells (APC)
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