IMM250H1 Study Guide - Final Guide: Complementarity-Determining Region, Antibody, B Cell

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Published on 6 Apr 2018
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ADAPTIVE IMMUNE RESPONSE
Main difference between adaptive and immune is the recognition of pathogens.
Lymphocytes recognize the specific antigen for adaptive immunity whereas
cells of innate immunity use the PAMPs.
BCR for B cells and TCR for T cells.
BCR has two binding sites and TCR has only one binding site for antigens.
B cell antigen has to be on the pathogen surface whereas T cell antigens
need not be on the pathogen surface.
The T cell and B cell has a very huge diversity.
V domain -- the antigen binding site is located here and is diverse
C domain -- no recognition ability and is used for other functions.
The variability is concentrated in the complementarity determining regions
(CDR)
Put together by the V, D and J segments in immunoglobin gene loci
V is variable
D is diversity
J is joining
Clonal Selection Theory: Each cell of lymphocyte will recognize a specific
antigen.
Clonal Selection theory proposed by Frank Mcfalane
Clonal Expansion
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