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IMM250H1 Study Guide - Final Guide: Natural Killer Cell, Fc Receptor, Mast Cell

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Dana Philpott
Study Guide

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T cell and B cells
B cell will directly see the antibody and secrete antibodies
T cell help the B cell to either become plasma or memory cell
F(ab) has to neutralize and stop the microbe form entering the host cell
and also recognizes the antigen.
Fc (stem) will activates complements and kill the pathogens
The constant part usually determine the effector functions of the
Antibody classes:
IgD -- blood and tissues in the inflammation sites
IgM -- first one produced because the gene segment for this is the first
IgG -- secondary response is dominated usually -- in tissues and blood --
important for biding to Fc receptor -- also involved in the opsonization
IgA -- secondary response is dominated
IgE -- secondary response is dominated -- tissues and mast cells -- very
specialized -- binds to the Fc receptor without the presence of antigens
and when antigen comes, the mast cell will granulate -- atopic people have
great number of IgE
IgA is found in secretions and is resistant to stomach acid
Polyclonal: variety of antibodies for
Monoclonal response: antibody specific for a particular pathogen --good for
T-B cell conjugate:
CD40 and CD40L interaction is necessary.
Different antibody classes are defined based on their:
Fc regions
Variable region only determines the specificity
Mucosal sites are normally protected by IgA
IgG is involved in complement activation, opsonisation and killing by natural
killer cells.
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