IMM250H1 Study Guide - Final Guide: Immunoglobulin M, Experimental Autoimmune Encephalomyelitis, Reassortment
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UNIVERSITY OF TORONTO
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IMM250H1S
April Examination 2017
Duration - 2 hours
No aids allowed. Please use pencil.
After completing this exam,
you may NOT take the exam paper with you.
This test consists of a total of 58 multiple-choice questions, and is
worth 50% of the final course grade
BE SURE TO COMPLETE
YOUR NAME AND STUDENT NUMBER
ON THE SCANTRON SHEET
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1.!Which!of!the!following!is!1.#),,2#&!about!the!TCR?!!
A. Composed!of!2!identical!α!chains!and!2!identical!β!chains!
B. Found!in!complex!with!CD3!
C. Is!assembled!through!gene!rearrangement!like!the!BCR!
D. Is!composed!of!a!variable!region!and!a!constant!region!
Ans.!A!
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2.!Antigen!presenting!cells!able!to!activate!naïve!T!cells!are:!
A. B!cells!
B. Macrophages!
C. Dendritic!cells!(DC)!
D. Any!of!the!above!
Ans.!C!
3.!When!a!naive!T!cell!interacts!with!an!activated!DC:!
A. The!T!cell!provides!cytokines!that!induce!DC!proliferation!
B. The!DC!provides!cytokines!that!influence!T!cell!differentiation!in!different!T!
helper!subsets!
C. The!DC!provides!signal!1!and!signal!2!of!activation!to!antigen-specific!T!cells!
D. Both!B!and!C!are!correct!
Ans.!!D!
4.!The!T!cell!ligand!for!B7!molecules!is!
A. CD28!
B. TCR!
C. CD3!
D. CD8!
Ans.!A!
5.!What!is!1.#),,2#&!about!the!co-receptors!CD4/CD8?!
A. Interact!with!MHC!class!II!and!class!I,!respectively!
B. Directly!contact!the!peptide!presented!by!MHC!molecules,!stabilizing!the!
TCR/peptide!interaction!
C. Either!CD4!or!CD8!is!expressed!on!mature!T!cells!
D. The!expression!of!either!CD4!or!CD8!is!established!in!the!thymus!during!T!
cell!development!
Ans.!B!
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6.!Which!is!the!main!function!of!CD8+!T!cells?!
A. Helping!B!cells!
B. Killing!of!virus-infected!cells!
C. Secretion!of!cytokines!such!as!IL-4!
D. All!of!the!above!
Ans.!B!
7.!An!effector!T!cell:!!
A. Has!encountered!antigen!
B. Might!secrete!cytokines!
C. Might!kill!virus-infected!cells!
D. All!of!the!above!is!correct!
Ans.!D!
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8.!TH1-derived!cytokines!such!IFN-γ!are!important!for:!
A. Effective!cell-mediated!defense!against!the!protozoan!parasite!Leishmania!
B. Effective!IgE-mediated!defense!against!the!protozoan!parasite!Leishmania!
C. The!activation!of!mast!cells!
D. All!of!the!above!
Ans.!A!
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9.!An!important!function!of!IL-4!is:!
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A. To!provide!a!signal!to!activated!B!cells!for!the!production!of!opsonizing!
antibodies!
B. To!induce!IgE!production!
C. To!support!macrophage!activation!
D. To!increase!the!expression!of!MHC!molecules!and!support!antigen!
presentation!
Ans.!B!
10.!When!molecules!and!cells!are!first!taken!up!by!the!lymphatic!system!they!travel:!
A. From!the!tissues!to!draining!lymph!nodes!
B. From!secondary!lymphoid!tissues!to!the!heart!
C. From!the!primary!to!secondary!lymphoid!tissues!
D. From!the!heart!to!secondary!lymphoid!tissues!
Ans.!A!
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Document Summary
After completing this exam, you may not take the exam paper with you. This test consists of a total of 58 multiple-choice questions, and is worth 50% of the final course grade. A: antigen presenting cells able to activate na ve t cells are, b cells, macrophages, dendritic cells (dc, any of the above. D: the t cell ligand for b7 molecules is, cd28, tcr, cd3, cd8. A: what is incorrect about the co-receptors cd4/cd8, interact with mhc class ii and class i, respectively, directly contact the peptide presented by mhc molecules, stabilizing the. Tcr/peptide interaction: either cd4 or cd8 is expressed on mature t cells, the expression of either cd4 or cd8 is established in the thymus during t cell development. 2: which is the main function of cd8+ t cells, helping b cells, killing of virus-infected cells, secretion of cytokines such as il-4, all of the above.
