IMM250H1 Study Guide - Final Guide: Innate Immune System, Adaptive Immune System, Hematopoietic Stem Cell

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16 Jul 2018
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Imm250 lecture 5 introduction to the adaptive immune system. Not smart immune system, it reacts but does not remember. Recognize molecular structures (has the capacity to recognize any molecular structure) Lymphocytes (kind of leukocyte, are 2 types = t cells + b cells) Stronger/faster immune response to subsequent infections from same pathogens. = physical barriers (skin)/chemical barriers (ph)/biochemical barriers to keep pathogens out (skin, saliva, mucosal barriers) = triggers inflammation, complement, phagocytosis, targeted cell lysis. = b cells (antibodies), th cells (cytokines), tc cells (cytolysis = kill targets) Entry of internal threat recognition response return to resting (homeostasis) Homeostasis important because: do not want adaptive system to be focused on specific pathogens, need adaptive system to retain broad specificity. Pamps = (cid:373)ol(cid:859)(cid:272) o(cid:374) surfa(cid:272)e of pathoge(cid:374)s that activate innate immune system. Recognized by prrs on innate immune cells = tlrs, nod receptors. Antigen = macromolecule/protein/carbohydrate expressed exclusively by one pathogen, each pathogen has multiple antigens.

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