IMM250H1 Study Guide - Comprehensive Final Exam Guide - Cytokine, Antigen, Antibody
Document Summary
Lecture 1: the i(cid:373)(cid:373)u(cid:374)e syste(cid:373) fro(cid:373) historical to (cid:373)oder(cid:374) perspectives. Louis pasteur: realized he could induce acquired immunity in chickens, he made two major discoveries, fermentation, pasteurization, disproved the spontaneous generation of microorganism. Antigens stimulate the clonal proliferation of lymphocytes that make an antibody that recognizes a particular antigen. Lymphocytes: two major types of lymphocytes that look the same up until they mature, b cell: produce antibodies. Differentiate into plasma cells: t cell: produce cytokines. Lecture 2: i(cid:374)(cid:374)ate i(cid:373)(cid:373)u(cid:374)ity: first li(cid:374)e of defe(cid:374)se. Requirements: there are 8 requirements for infectious disease: Invasion through a portal of entry: reservoir, transmission to host, adherence to host tissue, temporary evasion of host defenses, disease: interference with normal host function, exit and transmission. Pylori: causes ulcers - proven by marshall, used to be part of normal microbiota but in late 90s became eradicated through antibiotics. In immunocompromised patients, many free-living bacteria an can cause disease.
