IMM250H1 Study Guide - Midterm Guide: Mhc Class Ii, Haplotype, Clonal Anergy
Document Summary
Detection system that targets: broadly conserved microbial molecules called pathogen associated molecular patterns (pamps): lps, peptidoglycan , danger associated molecule patterns (damps): non infectious inflammation (stress of cell death leads to the release of intracellular compounds that are normally hidden from the immune system) Steps: a single progenitor cell gives rise to a large number of lymphocytes, each with a different specificity, selection step: removal of potentially self reactive immature lymphocytes by clonal deletion. Th2 cells: mediators will eosinophils, mast induce the differentiation of into plasma cells. induce pathogen attract cells and. 4 key families of cellular receptors: toll like receptors: tlrs; tm receptors that have their ligand binding domain either in the extracellular environment or in endosomes, c type lectin receptors: clrs; soluble receptors that detect pathogens (complement system, rigl like receptors: rlrs; cytoplasmic rna helicases that detect viruses by recognizing nucleic acids, nod like receptors: nlrs; cytoplasmic sensors.
