IMM250H1 Final: coordinating immune cell encounters
Document Summary
Lecture nine: coordinating immune cell encounters lymphocyte migration. :lymphatic vessels are interspersed with organized lymphatic organs called lymph nodes. *efferent lymphatic : leaves the lymph nodes and returns to the blood for re-circulation. : drains the tissues and brings lymph into the lymph nodes. *chemokine: (similar to a cytokine) soluble protein secreted by cells to communicate to other cells. : forms a gradient so that a cell can sense its way toward an appropriate location. : directs traffic of lymphocytes throughout the body. the chemokine gradient is emitted from the lymph nodes. *the chemokine by itself is not strong enough to draw the t cells. *adhesion molecule: proteins at the cell surface that mediates binding between 2 different cells. : in the case of lymphocytes flowing in the blood, allows lymphocytes to stick to entry points into lymph nodes. adhesion molecule on t cell surface binds with a receptor on the target cell surface.
