IMM250H1 Study Guide - Midterm Guide: Cytotoxicity, Blood Plasma, Complement System
Document Summary
Very unusual for hydrophobic transmembrane b/c they are +vely charged: should disrupt ability to stay in membrane. But, exist for an important reason (to be discussed later) Cd4 and cd8 cell surface proteins of t cells ig superfamily members. Bind to conserved region of mhc receptor to stabilize interaction. T cell can respond effectively to antigen. Passes signals that lead to t cell activation. Cd8: 1 ig domain; + form a heterodimer. Ensures right class of t cell associates w/ appropriate mhc receptor. Killer t cells mhc class i = cd8+ Helper t cells mhc class ii = cd4+ (recall: helper t cells activate b cells + humoral response: some exceptions. Cytoplasmic domain of cd4 and 8 pass signals to t cell. T cell receptor does interacting on outside. Need cd8 + cd4 to pass signal into cell + to make sure binding is correct. Igg [monomer] cellular + humoral responses. Secreted by plasma cells, on surface of memory cells.
