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IMM250H1 (46)
Final

final review - lymphocyte

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School
University of Toronto St. George
Department
Immunology
Course
IMM250H1
Professor
Victor Barac
Semester
Fall

Description
Antigen Processing and Presentation MHC antigen presentation Antigen processing in a nutshell – Proteins from pathogens are cleaved into peptides – Peptides are inserted into MHC groove – MHC presents peptide to naive T cells  T cells mature and start immune response  T cells only recognize antigens that are... o Peptide antigens o Linear epitopes o Cell surface antigens in self MHC Proteasomes – 4 rings of protein sub-units form a cylinder – Ubiquinated proteins go inside  smaller peptides come out – During immune response:  IFN (interferon) γ induces LMP2 + LMP7 (genes located in MHC) + MECL-1 to be added   Preferentially generate 6-12 aa peptides w/ hydrophobic C-terminal or basic resides o  MHC Class I compatible TAP proteins = Transporters associated with Antigen Processing – TAP-1 & TAP-2 = genes in MHC induced by IFN-γ – Sit in RER membrane and import peptides made by protesomes from cytosol – Preferentially transports peptides 8 aa or longer w/ hydrophobic or basic C-terminal ends   MHC Class I compatible Adjuvants ... the immunologist’s dirty little secret... – In o
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