🏷️ LIMITED TIME OFFER: GET 20% OFF GRADE+ YEARLY SUBSCRIPTION →
Log in
HomeStudy Guides420,000CA160,000

IMM250H1 Study Guide - Final Guide: Endosome, Tap1, Antigen Processing

55 views2 pages
School
UTSG
Department
Immunology
Course
IMM250H1
Professor
Victor Barac

For unlimited access to Study Guides, a Grade+ subscription is required.

Document Summary

Proteins from pathogens are cleaved into peptides. Mhc presents peptide to naive t cells. T cells mature and start immune response. T cells only recognize antigens that are: peptide antigens, linear epitopes, cell surface antigens in self mhc. 4 rings of protein sub-units form a cylinder. Ubiquinated proteins go inside smaller peptides come out. Ifn (interferon) induces lmp2 + lmp7 (genes located in mhc) + mecl-1 to be added. Preferentially generate 6-12 aa peptides w/ hydrophobic c-terminal or basic resides: mhc class i compatible. Tap proteins = transporters associated with antigen processing. Tap-1 & tap-2 = genes in mhc induced by ifn- . Sit in rer membrane and import peptides made by protesomes from cytosol. Preferentially transports peptides 8 aa or longer w/ hydrophobic or basic c-terminal ends. In order to induce an immune response, protein antigens must be mixed with adjuvant. A mix of bacterial products that activate innate responses. Initiate the 2nd signal (cytokines or inflammatory innate responses)

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers

Related Documents

IMM250H1 Lecture Notes - Lecture 6: Minnesota State Highway 7, Cd28, Hematopoietic Stem Cell Transplantation
lemonhamster432
IMM250H1 Lecture Notes - Lecture 7: Major Histocompatibility Complex, Antigen-Presenting Cell, Lymph Node
taupeturtle966
IMM250H1 Lecture Notes - Lecture 5: B Cell, Herd Immunity, Antigen
lemonhamster432

Related Questions

Immunology worksheet help?

1. In people infected with human cytomegalovirus, class I MHC andb2-microglobulin are produced, but very little mature class I MHCis found at the cell surface. Inhibition of which of the followingmolecules by human cytomegalovirus may account for thisphenomenon?
A. TAP
B. Ii
C. TCR
D. CLIP
E. RAG
2. Your chances of having the same MHC haplotype as your siblingare:
A. 1:2.
B. 1:4.
C. 1:16.
D. 1:8.
E. 1:1.
3. Which of the following is the BEST example of self-MHCrestriction of T cells?
A. A T-cell clone is deleted when it binds too tightly to selfMHC.
B. A T-cell clone responds more vigorously to a self-peptide thana foreign peptide.
C. A T-cell clone recognizes foreign MHC.
D. A T-cell clone only recognizes foreign peptides when presentedby self MHC.
E. All of the above
4. MHC molecules:
A. are conserved between individuals.
B. bind repeating patterns found on pathogens.
C. are recognized by T cells.
D. are membrane-bound molecules found exclusively on T cells.
E. are secreted by T cells and bind and neutralize antigen in theserum.
5. Tasmanian devils are a largely inbred population with littlediversity in the MHC. Which of the following would be a likelyoutcome of this?
A. They would compensate for low diversity in the MHC with highdiversity in the TCR.
B. They would compensate for low diversity in the MHC with highdiversity in the BCR.
C. They would rely only on innate immune responses.
D. They would be at higher risk of infection.
E. All of the above
6. How many different MHC classical class I proteins does eachnucleated cell in a human heterozygous at the MHC locusexpress?
A. Six
B. Two
C. Three
D. One
E. None. Only APC express class I.
7. MHC polymorphisms tend to cluster:
A. in the peptide-binding groove.
B. in the transmembrane domain.
C. in the coreceptor contact residues.
D. in the framework region.
E. All of the above
8. A mutation that renders the MHC class II molecule DMnonfunctional would likely lead to:
A. cells with no class II MHC.
B. a deficiency in CD8+ T cells.
C. cells with class II MHC only bound with CLIP.
D. cells with class II MHC bound with a variety ofself-antigens.
E. cells with no DO.
9. The human MHC locus is one of the most polymorphic regions ofthe genome. What does this mean?
A. This region is regulated by many different mechanisms.
B. Sequence variability is low in this region.
C. There are many introns in this region.
D. There are many different alleles of these genes.
E. It has the most different genes.
10. Which of the following is an example ofcross-presentation?
A. An exogenous peptide being presented on MHC class II
B. A B-cell antigen being presented to a T cell
C. An endogenous peptide being presented on MHC class I
D. An endogenous peptide being presented on MHC class II
E. An exogenous peptide being presented on MHC class I