03 - Innate Immunity II.docx

3 Pages
123 Views
Unlock Document

Department
Immunology
Course
IMM250H1
Professor
Victor Barac
Semester
Fall

Description
Innate Immunity II Acute Phase Response – Δ in blood in early phase of immune response st Involves protein and cellular elements – 1 macrophages/neutrophils to arrive release cytokines  Tumour necrosis factor α  TNFα  Interleukin 1 and 6 (IL-1, IL-6) o Causes  body temperature, inflammation – Fibrinogen: starts clotting cascade  Clots bvs downstream of injury so infection cannot spread  Problems: flow backup = inflammation, swelling  loosen bv endothelial lining  blood gets into ECM o Allows immune cells to move easily between cells to kill pathogens Complement: group of blood proteins that recognize and destroy microbes Overview of the complement cascade Overview of the main components and effector actions of complement – In innate immune system:  Alternative pathway o Proteins: C3 C6 Factor B Unique to C7 Common to all * See Fig 2.26 for list of fxns Factor D alternative C8 pathways for all compliment proteins pathway C5 C9  Lectin pathway – In adaptive immune system: classical / humoral pathway  Antibodies recognize, compliment (innate) destroys – Normally inactive  Activation by sequential proteolysis  Products can bind to microbial surfaces (or to antibodies bound to microbes)  Inhibited by regulatory proteins found on host cells Complement Activated by Alternative Pathway – Functions of C5a  Activates phagocytosis of C3b opsonized pathogens bound to Complement Receptor 1  Causes chemotaxis of macrophages and neutrophils thorugh C5a receptor
More Less

Related notes for IMM250H1

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit