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Department
Immunology
Course
IMM250H1
Professor
All Professors
Semester
Winter

Description
January 23DRAW SCHEMESSpecial K situation low responder mouse which means hole in T cell repertoire of certain mouse strain that cannot recognize antigen X within MHC expressed in that strainAssume P1 is BALBcnonresponder to special pan x black6 is high responder meaing it can recognize antigen x within MHC class Mouse is F1highresponder animalresponse to antigen presented by Separate different T cell populations on basis of restriction Use different pans that have antigen presenting cells plus antigen No population able to kill targets that are H2d plus x while have population found in adherent cells when use H2b plus x plate and nonadherent population when use H2d plus x cells Hole in repertoire refers to antigen x only Low responderT cell repertoire has no TCR able to see special case antigen x in context of certain MHC allele because hole in repertoire P1 into F1 chimeraChimerasKnow the rulesin lecture 3 8Questions
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