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study notes for lecture three: innate immunity

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University of Toronto St. George
Dana Philpott

Lecture THREE: INNATE IMMUNITY *innate: property of something or action that is essential and specific to that thing or action and is wholly independent of any other object, action, consequence; inborn innate immunity adaptive immunity conserved throughout evolution relatively recent 500 million years ago in all multicellular organisms unique to vertebrates organisms possess a set number of recognition molecules infinite number of recognition moleculesantibodies cells are immediately active (through the ability to mutate genes, we can have millions of combinations of has no memory antibodies that are able to recognize millions of antigens) cells require priming provides memory of infection INNATE &ADAPTIVE IMMUNITY WORK TOGETHER IN CONTROLLING INFECTION Type of Immunity - Effect no innate immunity - infections cannot be controlled at all (innate immunity is required to initiate adaptive immunity) innate immunity, no adaptive immunity - infection is controlled at some rate (by innate immunity) but microbial growth continues and cannot be cleared innate immunity + adaptive immunity - infections are cleared (by innate and adaptive immunity) HOW DO CELLS KNOW SOMETHING IS FOREIGN Dr. Charles Janeway Dr. Polly Matzinger - recognition of exogenous (non-self) microbial products 70.4J3L9L4341034J034:8,3J078LJ3,O8 ::consider the splinter = covered with bacterial products which are brought ::when a splinter occurs it causes a lot of damage to the cells in the into our system which is what the innate system responds to 03;L7432039,3L989K0574:.9870O0,8017429K0L3J.0OO89K,9L3L9L,90 immune responses they are both right innate immunity depends on the recognition of: *MAMPs: microbial-associated molecular patterns, signatures of microbial infections as they are pieces of the microbe; represent structural components of microorganisms unable to be modified *DAMPs : danger-associated molecular patterns, danger signals released from dead or dying cells
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