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study notes for lecture eight: priming the T cell response

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Lecture: EIGHT: PRIMING THE T CELL RESPONSE REVIEW adaptive immunity adaptive immune response is one of antigen-specific lymphocytes (B and recognition mechanisms of adaptive immunity T cells) to the antigen slow = days to weeks includes the development of immunological *memory variable = can handle a wide range of pathogensantigens *memory : ability to respond to the antigen of the individual infected with the numerous highly selective specificities same antigen improves during the response humoral VS cellular B cell response that makes antibodies *humoral immunity : antibody-mediated specific immunity made in a *cell-mediated immunity : any adaptive immune response in which humoral response antigen-specific T cells have the main role can be transferred to unimmunized recipients by using immune serum cannot be transferred to a naive recipient with serum antibody containing specific antibodies first noted with DTH response adaptive immune responses generated by clonal selection of lymphocytes (1 lymphocyte sees 1 antigen) distinct from innate and non-adaptive immunity {which are not mediated by clonal selection} hallmarks include *specificity: immune responses are specific for antigenic determinants or epitopes *diversity: vertebrate immune system has the capacity to recognize ~10 antigensdistinct epitopes through their immune receptors (B and T cells) *memory: 9K0L22:3088902K,89K0.,5,.L99470202-07570;L4:8O03.4:39070,39LJ038,37085432470011L.L039O *selfnon-self discrimination the immune system has the capacity to recognize foreign peptides from self peptide (autoimmunity VS tolerance) *self limitation: immune responses are transient and tightly regulated (programmed cell death and apoptosis) recall what happens during a host response vast majority of T cells that have undergone clonal expansion will die during the immune response and leave a small number of memory cells to circulate in the body antigens at the molecular level, an antigen is characteriz0-L9,-LOL994-0-4:3,99K0,39LJ03-binding site of an antibody *antibodies tend to discriminate between the specific molecular structures presented on the surface of the antigen usually proteins or polysaccharides lipids and nucleic acids are only antigenic when combined with proteins and polysaccharides *non-selfnon-microbial exogenous antigens: pollen, egg whites and proteins from transplanted tissuesorgans 1
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