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study notes for lecture nine: coordinating immune cell encounters

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Dana Philpott

Lecture NINE: COORDINATING IMMUNE CELL ENCOUNTERS lymphocyte migration *lymphatic system309Z47N41.43:L989K,9.,77,.O0,71O:LO25K :lymphatic vessels are interspersed with organized lymphatic organs called lymph nodes *efferent lymphatic : leaves the lymph nodes and returns to the blood for re-circulation *afferent lymphatic: point of entry for lymph : drains the tissues and brings lymph into the lymph nodes *chemokine : (similar to a cytokine) soluble protein secreted by cells to communicate to other cells : forms a gradient so that a cell can sense its way toward an appropriate location : directs traffic of lymphocytes throughout the body lymphocytes respond to chemokine gradients the chemokine gradient is emitted from the lymph nodes *the chemokine by itself is not strong enough to draw the T cells *adhesion molecule: proteins at the cell surface that mediates binding between 2 different cells : in the case of lymphocytes flowing in the blood, allows lymphocytes to stick to entry points into lymph nodes adhesion molecule on T cell surface binds with a receptor on the target cell surface adhesion molecules tether the chemokine gradient + adhesion molecule interactions draws the T cell *high endothelial venule (HEV): portal of entry for lymphocytes circulating in the blood to directly enter a lymph node ,8O25K4.908J49K74:JK9K0+89K08000;079KL3J9K030094800849K0.,308.,5017429K0-O44 and enter the lymph node lymphocytes have finger-like structures = microvilli that touch adhesion molecules adhesion molecules are located at parts of the blood vessel wall adjacent to the lymph node these mechanisms allow tethering of these molecules to adjacent lymph nodes they respond to chemokine gradients as lymphocytes travel in the blood, they interact with venule chemokine secretion causes a slowing of the lymphocyte the adhesion receptor interaction allows the T cell to escape from blood circulation it allows naive lymphocytes to enter the lymph node where there is the most antigen presented *fever increases the intensity of adhesion molecules as well as chemokine secretion 1
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