MGY250H1 Study Guide - Final Guide: Ribosomal Rna, Rna Polymerase I, Transfer Rna
17 Dec 2016
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Document Summary
C value [genome size] is not proportional to complexity of a species. Have perspective on the gene content of the mitochondrial and nuclear genomes. Nuclear genome: 5-6% of it is highly conserved, almost half is transposon-based repeats. Mitochondrial genome: smaller than nuclear genome and majority is highly conserved, unlike nuclear genome. Protein synthesis and export, rna maturation, dna synthesis/telomere function, gene regulation. Many non coding rna do not have a function. Using a phylogenetic tree to compare sequences between species. Looking for footprints where sequences have been unaltered/minimally altered". Good way to find functional elements of dna. Mis-pairing during meiosis leads to duplications or deletions. The makeup of the genome; differences in scale and roles. Almost half of the nuclear genome is made of poorly conserved transposon repeats. Exon shuffling can be mediated by retrotransposons. Lines and sines also mediate non-homologous recombination give rise to duplications and deletions.
