MGY377H1 Final: Study notes for exam

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redtermite204

27 Dec 2011

School

UTSG

Department

Molecular Genetics and Microbiology

Course

MGY377H1

Professor

William Navarre

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Document Summary

Alter signal transduction: decreased il-9 production pro inflammatory. Block delivery with nadph oxidase and inos: prevents exposure of bacteria to reactive oxygen and nitrogen intermediates. Modulate actin dynamics at the salmonella-containing vacuole. Result from fusion of late endocytic compartments with scv. Require at least four effectors for formation/stability: sifa, ssef, sseg. recruits host dynein, a microtubule motor complex. may play role in acquiring nutrients from host cell via the secretory pathway: sopd2. Dynamics of scv positioning: sifs disappear twentyfour hours after infection. Escape phagosome using various virulence factors, mechanisms of action for most unclear. Have metabolism that takes advantage of nutrients in cytosol. Most cytosol-adapted pathogens undergo actin-based motility in cytosol of host: allows cell to cell spread. bacteria or other cellular cargo sequestered in double membrane structure called autophagosome which undergoes maturation processes that eventually results in fusion of lysosomes, degradation of cargo and recycling of macromolecules.

Related Questions

Salmonella typhimurium is a food-borne bacterial pathogen that can cause severe gastrointestinal disease. Salmonella is often phagocytosed by macrophages that normally destroy bacterial pathogens, but this bacterium is somehow able to prevent the complete maturation of phagolysosomes. Salmonella is able to tolerate the low pH of phagolysosomes, and in fact responds to the drop in pH by secreting toxins that interfere with other cellular responses. You can expect ______________ to contribute to the survival of a bacterium within an Salmonella-containing phagosome, compared to a healthy phagolysosome?

decreased activity of acid hydrolases

increased activity of acid hydrolases

decreased import of H+ ions

increased import of H+ ions

My guess is decreased activity of acid hydrolases but I'm not sure.

What is extravasation?

a. The expansion of joints between endothelial cells allowing for the migration of immune cells and proteins access to infection sites.

b. Recruitment of macrophages to infected tissues.

c. The process by which Salmonella avoids killing by phagocytic cells.

d. Coating of a pathogen with C3b for uptake by macrophages.

Atypical hemolytic uremic syndrome results from mutations in which complement component?

a. Factor I

b Factor H

c. C3b

d. CR1

plummouse722

1. C3a and C5a are proteins which effectively _____.

a.Opsonize invading pathogens

b.Recruit immune cells to infection site

c.Form pores in bacterial and fungal cell membranes

d.Cleave covalent bonds in peptidoglycan

2. Some pathogenic bacteria produce ______ which protect the organism against the oxidative burst from _________.

a.Catalase i. Phagocytic cells

b.Nitric oxide ii. Red blood cells

c.Superoxide Dismutase iii. Cytokines

d.C3 convertase iv. B Cells

3. What is extravasation?

a.The expansion of joints between endothelial cells allowing for the migration of immune cells and proteins access to infection sites.

b.Recruitment of macrophages to infected tissues.

c.The process by which Salmonella avoids killing by phagocytic cells.

d.Coating of a pathogen with C3b for uptake by macrophages.

4.Atypical hemolytic uremic syndrome results from mutations in which complement component?

a.Factor I

b.Factor H

c.C3b

d.CR1

MGY377H1 Final: Study notes for exam

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