MGY377H1 Final: Study notes for exam

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Antibiotic substance produced by microorganism or a similar product produced wholly or partially by chemical synthesis and in low concentration inhibits growth of or kills microorganism. Discovers salvarsan toxic contains arsenic but more toxic to syphilis than people. Discover protosil, an antibiotic: which is metabolized to active form by animal cells. Selective toxicity: against target pathogen but not against host, high ld50. Lethal dose fifty percent measure of drug toxicity/lethality against host: minimal inhibitory concentration and or minimal lethal concentration low ideally. measure of the concentration of the antibiotic necessary to inhibit growth of target bacterial cell. mlc is measure of concentration of antibiotic necessary to kill target pathogen: therapeutic index is c toxicity to host divided by c inhibitory to bacteria. Lack of side effects unique targets in pathogen. Alcohol and bleach kill bacteria they are not good antibiotics because you cannot get high enough concentration to kill bacteria.

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