MGY377H1 Final: Study notes for exam
Document Summary
Bacteria respond to varied environmental cues like oxygen, ph, temperature, membrane stress. Change in gene expression due to change in environment. Can result in cross protection: pretreatment at low dose of a stressor gives better protection at high dose, basis of cross protection. generally cross protection occurs when protection against two apparently unrelated stresses utilize similar or identical defense systems. Alterations in rna polymerase through its association with alternative sigma factors. Most common way to transmit signals from outside cell to cytoplasm. Modular proteins involved: have domains that can be swapped to generate new signalling molecules. Involves a histidine kinase and a response regulator. hk sensor of environmental signals y transfers phosphate from atp to response regulator y found as homo dimer. rr controls response output y often dna binding protein y phosphorylated on an aspartic acid. Steps: a signal is detected by the periplasmic domain of the histidine kinase.