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Molecular Genetics and Microbiology
William Navarre

22Horizontal lateral gene transfer plays major role in prokaryotic evolution Transduction conjugation and transformation The five major pathogenicity islands of Salmonella typhimurium are all more AT rich than the rest of the genome Also have virulence plasmid Most horizontal transfer events decrease fitness They disrupt essential genesDisrupt regulation Disrupt metabolism System incompatibility Disrupt chromosomal packaging Phages HNSNucleoid binding protein that represses transcription Binds DNA with little sequence specificityprefers AT rich DNA HNS has poor DNA binding protein but it exhibits cooperative binding behaviouro Can nucleate at a highaffinity site and polymerize along AT rich tracts to generate extended footprints on DNA templates Regulates large number of genes obtained by horizontal transfer HNS can discriminate on the basis of AT content and lengtho Ignore smaller patches of foreign DNA Xenogeneic silencing Characteristic GCcontent of the bacterial genome can be exploited to reco
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