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Department
Molecular Genetics and Microbiology
Course
MGY377H1
Professor
William Navarre
Semester
Fall

Description
32 Bacterial pathogenesis Primary pathogenscause disease in healthy hosts Opportunistic pathogenscause disease only in immunocompromised patients Virulencemeasure of severity of disease o Infectious dose versus lethal dose LD50amount needed to kill half of host population Amount variesnot fixed number Hostpathogen interactions Infection cycleroute an organism takes from one individual to another Horizontal transmissionfrom one member of a species to anothero Can occur via fomites inanimate objects o Or vectors like animals Vertical transmission from parent to child Accidental transmissionhost who is not part of the normal infectious cycle unintentionally encounters that cycle Reservoiranimal bird insect that normally harbours the pathogen Pathogens use portals of entry best suited to their mechanisms of pathogenesiso By mouthfood or waterborne pathogenso Respiratory tractairborne pathogens Immunopathogensisoccurs when immun
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