NFS382H1 : Mineral Overview TT1.docx
15 Apr 2012
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Vd metabolites from the oxidation and hydroxylation of : * studies have shown that going up to. 10 000 iu doesn"t have toxicity effects thus. 60% bound to dbp and is deposited to the adipose, muscle, liver. Dietary: 50% absorbed in all 3 parts of small intestine. Lumen has pancreatic lipase and helps form micelle. Passes through bbm by diffusion chylomicron exits at blm as. Active vd enters cell by dbp, which is then recycled out. Vd binds to vita receptor forming a heterodimer. This binds to other proteins components and helps inhibit/synthesize protein. It is carboxylated by vit: plays role in mineralization and is indicator of ob activity. Signal transduction pathway linked to cell membrane vdr (fast signaling) Calciriol binds to cmvdr and triggers opening of ca channels thus more ca in ob and skeletal muscles. Mg helps with pth secretion but too much mg inhibits. Mg and ca compete for kidney transport system.
