PCL477H1 Study Guide - Final Guide: Cdc45-Related Protein, Cyclin E, Cyclin D

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taupewallaby501

9 Dec 2016

School

UTSG

Department

Pharmacology and Toxicology

Course

PCL477H1

Professor

J.Peter Mc Pherson

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Document Summary

Cell cycle: replication of dna and splitting of nucleus, well defined stages, and conserved in. The s-synthesis phase and the m-mitosis phase. Dna replication starts as soon as mitosis ends and takes a hr for completion of one cycle of cell division. Control of cell cycle: an embryo of a significant size with cells on the inside in contrast to outside. Outside is exposed to environment where more nutrients are readily available. Period when signals intervene to influence the cell"s decision to initiate s phase: there is another gap called g2 that occurs between s and m and influences the cell"s decision to initiate m phase. To enter s or m phase activation of cdks is necessary (master regulators) Cdks require binding to cyclin to become catalytically active (cdk cyclin complex is the active form) Only cdk1 (cdc2) is found in yeast, as eukaryote complexity increases the need for cdks is increased.

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A condition characterized by the growth of endometrial cells in areas other than the endometrium is called

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A standard screening test for cervical cancer is called

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The period of prenatal development in which the basic parts of the organ systems are formed is the

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Detection of

Spell check is used by pregnancy test kits to detect the early stages of pregnancy.

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The actual gene sequence governing the expression of a trait is called a

Spell check , whereas the physical expression of this trait is the PHENOTYPE , which can also be defined as the physical expression of a gene.

Question 16

Down syndrome is a disorder where a person has an chromosome 21.

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A picture of all chromosomes taken in metaphase and used for analysis is called a

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A pregnancy where the fertilized egg implants in an area other than the uterus is called

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The basic building blocks of DNA are called

Question 20

Monosomy of the X chromosome characterized by a short stocky neck, underdeveloped secondary sexual characteristics, and infertility is called

syndrome.

Question 21

A deletion of the short arm of chromosome 5 with a typical cry that resembles a meowing cat characterize

Question 22

A serious psychological disorder characterized by the fear of becoming obese is called

Question 23

Diffusion of gases between capillary beds and tissues is called respiration.

Question 24

The destruction of alveoli by irritants such as cigarette smoke and agricultural dust is found in a disorder called

Question 25

Of the three types of skin cancer which are the most likely to metastasize

Question 25 options:

Melanoma

Squamous cell carcinoma

Basal cell carcinoma

All of the above have equal ability to metastasize

Question 26

Cancer of this organ/gland causes the most deaths annually

Question 26 options:

Lung

Breast

Prostate

Bladder

Question 27

The correct order of stages of the cell cycle that a new cell will go through immediately after being produced by mitosis is

Question 27 options:

S, G1, G2, M

G1, G2, M, S

G1, S, G2, M

M, G1, S, G2

Question 28

What is the purpose of DNA replication

Question 28 options:

To copy the information in a gene so that extra protein synthesis can be done

To make an RNA copy of the gene

To provide the cell with extra DNA in case the original gets damaged

To ensure that two cells produced by mitosis have the same genetic information as the parent cell

Question 29

Which of the following is not a function and/or advantage of mitosis

Question 29 options:

It can repair damaged tissue

Growth takes place through mitosis

It can replace old or damaged cells

All of the above are functions and/or advantages

Question 30

Which stage of the cell cycle occurs just after mitosis

Question 30 options:

Prophase

Save

Question 31 (1.5 points) Question 31 Unsaved

DNA replication is completed by the end of

Question 31 options:

Prophase

S phase

Question 32

Which of the following is NOT true of DNA

Question 32 options:

Generally double stranded

Stores the cell genetic information

Replicated by DNA polymerase

Contains A, C, U, and G

Question 33

These cell may enter G0 of the cell cycle permanently

Question 33 options:

Hepatocytes

Transformed cells

Neurons

Cells in the digestive system

Question 34

When a primary spermatocyte, goes through meiosis, how many mature sperm will be produced

Question 34 options:

Question 35

When a primary oocyte goes through meiosis, how many mature eggs will be produced

Question 35 options:

Question 9

Codominance is a form of inheritance in which two different allelesfor a gene are both expressed, and neither allele is dominant overthe other. One example of codominance is fur color in cattle; thealleles for red fur and white fur are codominant. If a homozygousred cow and a homozygous white bull mate, what would you expect tofind in their offspring?.912.l.16.2>

They will all have white fur.

Their fur will be a mixture of red and white hairs.

Their fur will be a lighter shade of red.

They will all have red fur.

Question 10

If a tRNA molecule has an anticodon which reads AUG, what will itmatch up with and what amino acid is it carrying?
.912.l.16.5>

	U		C		A		G
	UUU	Phenylalanine	UCU	Serine	UAU	Tyrosine	UGU	Cysteine	U
U	UUC	Phenylalanine	UCC	Serine	UAC	Tyrosine	UGC	Cysteine	C
	UUA	Leucine	UCA	Serine	UAA	Stop	UGA	Stop	A
	UUG	Leucine	UCG	Serine	UAG	Stop	UGG	Tryptophan	G
	CUU	Leucine	CCU	Proline	CAU	Hisitidine	CGU	Arginine	U
C	CUC	Leucine	CCC	Proline	CAC	Hisitidine	CGC	Arginine	C
	CUA	Leucine	CCA	Proline	CAA	Glutamine	CGA	Arginine	A
	CUG	Leucine	CCG	Proline	CAG	Glutamine	CGG	Arginine	G
	AUU	Isoleucine	ACU	Threonine	AAU	Asparagine	AGU	Serine	U
A	AUC	Isoleucine	ACC	Threonine	AAC	Asparagine	AGC	Serine	C
	AUA	Isoleucine	ACA	Threonine	AAA	Lysine	AGA	Arginine	A
	AUG	Methionine/Start	ACG	Threonine	AAG	Lysine	AGG	Arginine	G
	GUU	Valine	GCU	Alanine	GAU	Aspartate	GGU	Glycine	U
G	GUC	Valine	GCC	Alanine	GAC	Aspartate	GGC	Glycine	C
	GUA	Valine	GCA	Alanine	GAA	Glutamate	GGA	Glycine	A
	GUG	Valine	GCG	Alanine	GAG	Glutamate	GGG	Glycine	G

It is carrying arginine and will match with a CGU codon on themRNA.

It is carrying methionine and will match with a TAC codon on theDNA.

It is carrying methionine and will match with a UAC codon on themRNA.

It is carrying tyrosine and will match with a UAC codon on themRNA.

Question 11

While the DNA in a human skin cell was being replicated, a singlebase was miscopied. What will be the most likely result of this forthe cell in which it happened?.912.l.16.3>

All the proteins the cell creates from the miscopied strand willdo different jobs than the old ones.

If the new sequence codes for the same amino acid as theoriginal cell, it will function normally.

Both new DNA strands will end up together in a new cell, and theinaccurate one will be discarded.

Any miscopied DNA will be replaced with an accurate DNA copyonce the cell divides.

Question 12

A ferret's haploid number of chromosomes is 20. How would thenumber of chromosomes in the ferret's body cells compare to thenumber of chromosomes in its gametes?.912.l.16.17>

Its body cells would have 20 chromosomes, and its gametes wouldhave 40 chromosomes.

Its body cells and gametes would both have 40 chromosomes.

Its body cells and gametes would both have 20 chromosomes.

Its body cells would have 40 chromosomes, and its gametes wouldhave 20 chromosomes.

Question 13

A body cell is in the longest stage of its life cycle. The cellgrows, synthesizing proteins and increasing in size. Eventually,the cell will grow too large to carry out normal activities. Whichof the following is the best conclusion you can make about the lifecycle of this cell?.912.l.16.14>

The cell is close to the end of its life cycle, and a chemicalsignal will initiate cell death.

The cell is ready to undergo mitosis, and a chemical signal willsend the cell to prophase.

The cell is in the G1 phase of interphase, and a chemical signalwill send the cell to the S phase.

The cell is in the S phase of interphase, and a chemical signalwill move the cell to the G2 phase.

Question 14

While mRNA strands are being created a sequence is sometimesmiscopied. What is the best possible outcome for the cell shouldthis take place?.912.l.16.5>

The miscopied sequence codes for the same amino acids as theoriginal sequence.

The new sequence creates a protein that serves a differentfunction from the original.

The ribosomes will correct the mistake before the tRNA matchesan amino acid to it.

The mRNA will only be used to create non-critical proteins forthe cell.

Question 15

Over the last several decades, the scientific community hasgathered a large amount of information regarding genetics andgenetic variation. What are two main sources that lead toincreased genetic variation?.912.l.15.15>

Selective breeding

Gamete mutations

Recombination

Genetic drift

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PCL477H1 Study Guide - Final Guide: Cdc45-Related Protein, Cyclin E, Cyclin D

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