PCL477H1 Study Guide - Final Guide: Death Effector Domain, Mitomycin C, Crosslinking Of Dna
9 Dec 2016
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Designed to minimize interference or interruption of other cells. Designed to be cell contained (chromatin condensation, shrinkage of cytoplasm) Designed to break in fragments (nuclear fragmentation, cell fragmentation) Dna will condense and be cleaved, mitochondria is released into cytoplasm (release cytochrome. Signaling event on cell surface phosphatidylseriine within plasma membrane becomes flipped outside: gets bound by receptors on phagocytic cells (macrophages and dendritic cells)-> gets eaten, phagocytic cells secrete cytokines that inhibit inflammation. Cytosolic swelling and early loss of plasma membrane integrity. Cell contents leak out, leading to inflammation of surrounding tissues: results from mechanical damage or exposure to toxic chemicals- signal for help. A fuck ton of cisplastin 800um= necrosis in a few hours. 8 um cisplastin over 3 days = apoptosis. Mechanism for eliminating irreparably damaged cells that might threaten the health of organism: apoptosis is the consequence for dna damage. Anything that causes dsb in thymocytes- love to go under apoptosis,
