PHC320H1 Study Guide - Photodissociation, Hydrolysis, Acid Dissociation Constant

• School: UTSG
• Department: Pharmaceutical Chemical Engineering and Applied Chemistry
• Course: PHC320H1
• Professor: Shirley Wu

Document Summary

Solubility in hydrophilic & lipophilic solvents & dissociation constants (pka) o o: melting point o o o o o o. When the temperature of oil reaches tm of drug, 2 possible scenarios phase = true polymorphs (1) drug melts :formation of second liquid phase inside silicon oil (generally not miscible) = formation of globular (2) addition to formation of 2nd liquid phase, also see bubble formation (gas) = pseudo polymorphs (gas/bubbles indicate solvent escaping in heated environment ; thus, bubbles seen at temperature close to boiling point of solvent)*** Temperature o: molecular structure of solute o o o o o o o o. Addition / removal of polar or non polar group modulates solubility of drugs o o o: why reduce solubility of a parent drug (eg. by esterification)? (1) masking taste of parent drug (2) protecting parent drug from excessive degradation in the gut (3) increasing ease of absorption of drugs from gi tract.