PSL300H1 Study Guide - Midterm Guide: Activin And Inhibin, Epiphyseal Plate, Corpus Albicans
26 Jan 2013
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Purify extract and test for effect in biological assays. Case study: maintenance of blood pressure knowledge of the physiology of b. p. control allows treatments: May act on multiple tissues alter activity of target cells action must be terminated. Maintain homeostasis or cause change in many physio processes: case study: man with hyperglycemia hyperglycemic, too much insulin in blood. Cause: only makes proinsulin insulin f"n decline, overproduction due to stimulus of high [gluc: can check by testing for c-peptides in blood, types of hormones. Peptide/protein hormones (3+ aas: most of the hormones, made in advance & stored in secretory vesicles (like secreted proteins) release by exocytosis upon signal goes through same sequence of protein synthesis starting in rough er. Fsh glycosylated: water soluble (dissolved in plasma) i. e. , don"t need carrier. Short half-life in plasma (b/c unprotected: bind to membrane receptors final products cleaved during processing. But some act on pm receptors, producing fast action like peptides!
