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study notes for lecture two: endocrine physiology

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Department
Physiology
Course Code
PSL201Y1
Professor
Doug Mac Kay

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LECTURE TWO: ENDOCRINE PHYSIOLOGY
*endocrine physiology = hormone action
((endocrine system controls body functions))
Æhormones bind to receptors
Æbinding triggers signalling pathways within individual or groups of
cells
Æthe signalling pathways cause changes in cell activity
Æcell activity changes result in body function because cells
communicated with each other and regulate body function
example: growth hormone
Æexercise results in growth hormone secretion
Ægrowth hormone enters blood and binds to growth hormone
receptors on fat cell/adipocytes
Æbinding triggers multiple downstream signalling pathways
Æresults in fat breakdown for muscle energy
Æthis energy supplies the energy demands of exercise
Æbody systems do not exist within themselves
\Æbody systems need to communicate with each other to regulate body function
example: endocrine system and nervous system controls energy balance
*insulin action in the brain lowers liver glucose production in rodents
obesity & diabetes
Æhypo = too little insulin => increased glucose levels, increased appetite
Æresistance = too little effect
INSULIN
Binding Site
Mechanism
Effects
Other considerations
- brain
binds to a receptor in the brain
sends a signal via the efferent vagus that runs
between the brain and liver
o controls glucose production
¾ in diabetes and obesity,
LQVXOLQGRHVQ¶WZRUNDWWKH
level of brain function
- liver
binds to a receptor on the liver
o controls glucose levels by controlling
production in the liver
¾ lowers glucose levels
¾ controls how much you eat
classical endocrine glands
Æpineal
Æhypothalamus
Æpituitary
Æthyroid
Æparathyroid
Æthymus
Æadrenal
Æpancreas
Æovary
Ætestis
Æ*fat/adipocytes (leptin/adiponectin)
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Description
LECTURE TWO: ENDOCRINE PHYSIOLOGY *endocrine physiology = hormone action ((endocrine system controls body functions)) example: growth hormone hormones bind to receptors exercise results in growth hormone secretion binding triggers signalling pathways within individual or groups of growth hormone enters blood and binds to growth hormone cells receptors on fat celladipocytes the signalling pathways cause changes in cell activity binding triggers multiple downstream signalling pathways cell activity changes result in body function because cells results in fat breakdown for muscle energy communicated with each other and regulate body function this energy supplies the energy demands of exercise body systems do not exist within themselves body systems need to communicate with each other to regulate body function example: endocrine system and nervous system controls energy balance *insulin action in the brain lowers liver glucose production in rodents obesity & diabetes hypo = too little insulin => increased glucose levels, increased appetite resistance = too little effect INSULIN Binding Site Mechanism Effects Other considerations - brain binds to a receptor in the brain o controls glucose production in diabetes and obesity, sends a signal via the efferent vagus that runs L38:OL340839Z47N,99K0 between the brain and liver level of brain function - liver binds to a receptor on the liver o controls glucose levels by controlling lowers glucose levels production in the liver controls how much you eat classical endocrine glands pineal parathyroid ovary hypothalamus thymus testis pituitary adrenal *fatadipocytes (leptinadiponectin) thyroid pancreas www.notesolution.com
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