PSL440Y1 Study Guide - Final Guide: Prostaglandin, Calcitonin Gene-Related Peptide, Lesion

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10 Dec 2015
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Pain and its function: actively warns of potentially threatening stimuli. Different qualities sharp, aching, burning: primitive system that"s evolutionarily similar between species (same responses) Different dimensions of the pain experience: experience tends to be divided anatomically, sensory-discriminative ability to tell exactly where the pain is coming from; easy to do from surface of the skin, affective-motivational. Primitive system that"s evolutionarily similar between species (same responses) cognitive-evaluative. By cause: nociceptive pain to harm, to injure (due to something like a cut) Assessment of pain descending pathway go down into raphe area of midbrain descending projections (some serotinergic) to control flow of pain signal up excitatory pathway activating. Activated by tissue damaging stimuli can occur without damaging tissue: e. g apply a copper heating stimulus up to 45 degrees to produce a pain without damaging the skin. Present in almost all tissues: nociceptors in surface, deep tissue, perineum (like appendicitis)

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