BIOC 300B- Final Exam Guide - Comprehensive Notes for the exam ( 86 pages long!)
29 Mar 2018
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Document Summary
The ow of genetic information (central dogma: dna holds the master copy of genes, genes are transcribed into rna, rna is translated into a protein (the functional form) Note: sugar carbons are donated as 1", 2", 3" etc. to differentiate from carbons involved in. Dna = deoxyribose. the 2" carbon is missing an oxygen. Uracil (lacks a c-5 methyl group) in rna instead of thymine. Detection of mutational events that results in formation of uracil. 3" to 5" phosphodiester linkages ( phosphate group inbewtsween 3" and 5" oxygens on sugars) Phosphodiester bridge has -ve charge which repels nucleophilic species like hydroxide ions that can perform hydrolytic attacks on backbone -> maintains integrity of nucleic acids. Absence of 2" hydroxyl group in dna increases resistance to hydrolysis and is likely accountable for its greater stability than rna. Building blocks of nucleic acids play other roles in the cell (energy currency, molecular signals) Ex: adenosine, guanosine, cytidine, and uridine (rna)
