EPHE 242- Final Exam Guide - Comprehensive Notes for the exam ( 34 pages long!)

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Oxidation of glucose occurs in 3 metabolic pathways: glycolysis occurs in cytosol of cell, krebs cycle aka citric acid cycle, tricarboxylic acid cycle, occurs in matrix of mito, oxidative phosphorylation occurs across inner mito membrane. (cid:373)ea(cid:374)s (cid:862)splitti(cid:374)g of suga(cid:396)(cid:863), glu(cid:272)ose = suga(cid:396) a(cid:374)d lysis which means to cut to lyse. Over rxn of glycolysis is: glucose + 2nadh+ +2adp + 2pi 2 pyruvate + 2nadh + 2h+ + 2 atp. Note that during glycolysis no oxygen is consumed and no carbon dioxide is produces. Useful to cells b/c produces some atp. Step 1: enzyme hexokinase breaks glucose into glucose-6-phosphate (cid:271)y (cid:396)e(cid:395)ui(cid:396)es atp i(cid:374)put. Step 3: phosphofructokinase breaks fructose-6-phosphate into fructose-1,6-(cid:271)iphosphate (cid:271)y requires atp input. Step 4: aldolase breaks it into dihydroxyacetone phosphate. Step 5: triosephosphate isomerase breaks down into 2 glyceraldehydes-3-phosphate. Refer to pg 75 for complete details. Major reactants: 3 nad+, 1 fad, 3 h2o, 1 adp + 1pi.

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