BIOC 2010 Study Guide - Midterm Guide: Proline, Trypsin, Cyanogen Bromide
23 Apr 2016
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A prerequisite for determining its 3d structure. For understanding its molecular mechanism of action. Enabling sequence comparisons among analogous proteins (insights into protein function and evolutionary relationships) For developing diagnostic tests and effective therapies for diseases caused by mutations. We need to know the sequence to determine its 3d structure. It can tell us what the specific protein can do! The function of the protein might be. Study the evolutionary proteins among many protein classes. Mapping the specific mutations responsible for diseases/problems. It was the very first protein to have its sequence determined. It took about a dozen years of studying for this relatively small protein. A and b chain held by two disulfide bonds. Also a disulfide bond inside the a chain. Need to know where the disulfide bonds, which cysteines are involved. How many chains, their relative positions etc etc. Find what the amino terminal residue is/are.
