Biochemistry 2280 Topic 7 McLachlin.docx

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Department
Biochemistry
Course
Biochemistry 2280A
Professor
Christopher Brandl
Semester
Winter

Description
Topic 7 Lipids and biological membranes Readings: p.54-55, 70-71, 363-372 By the end of this topic, you should be able to: • Describe and distinguish between the different classes of lipids • Describe the biological roles of the different classes of lipids • Explain the properties of lipid bilayers, and why certain lipids form bilayers All cells are enclosed by a membrane composed of lipids, proteins and carbohydrates. Eucaryotic cells also have internal membranes that divide the cell into different compartments (Fig 11-3, p.364). Biological membranes have several important functions, including the following. 1. They separate the contents of a cell or organelle from the surrounding environment. 2. They control import and export of molecules (e.g., nutrients, waste, ions) into and out of the cell or organelle, using proteins that span the membrane. 3. They contain sensors or receptors that allow the cell to respond to external stimuli including communications from other cells. 4. They are involved in cell movement. Biological membranes are based on certain types of lipid molecules. Lipids are biological molecules that have little or no solubility in water, but are soluble in organic solvents. In addition to being structural components of biological membranes, lipids also function as energy storage molecules (see Topic 16), enzyme cofactors, signalling molecules, and pigments. Structurally, lipids may be divided into several different classes, some of which are described below (see Panel 2-4, p.70). Fatty acids: Hydrocarbon chains ending in a carboxylic acid group (Movie 2.2). Fatty acids usually contain an even number of carbon atoms, and range in length from 4 to 36 carbons. If the hydrocarbon chain has no double bonds, it is called saturated. If it has one double bond, it is called monounsaturated. If it has two or more double bonds, it is called polyunsaturated. The first C-C double bond in unsaturated fatty acids is usually between C9 and C10, counting from the COOH end; it is almost always cis, forming a kink in the chain. Any additional double bonds are usually at every third carbon, as in the 18-carbon fatty acid shown on the next page. O HO The structure of a fatty acid can be indicated by a short form in which the letter C is followed by the number of carbon atoms and double bonds in the fatty acid, separated by a colon. For example, the saturated fatty acid with 16 carbons would be represented C16:0. The 18-carbon unsaturated fatty acid shown below is most properly abbreviated 9, 12 C18:2 cis,cis-Δ, although sometimes the cis isomer or the positions of the double bonds are assumed, such that the abbreviation could be simply C18:2. In another nomenclature system, the double-bond position is counted from the methyl end of the molecule, and the number of the double-bonded carbon closest to the methyl end is given in brackets. In this system, the 18-carbon fatty acid shown below would be represented as C18:2(n-6). In older nomenclature, the terminal carbon is called the ω (omega) carbon, and sometimes you will see the abbreviation in the form C18:2(ω-6). Triacylglycerols: Glycerol is a three-carbon molecule with hydroxyl groups at each carbon (see figure). Triacylglycerols (also called triglycerides) are obtained by attaching a fatty acid to each hydroxyl via an ester linkage (see Panel 2-4, p.70). Most triacylglycerol molecules contain two or three different types of fatty acids. Triacylglycerol is used to store fatty acids as energy reservoirs in adipocytes. Glycerophospholipids: These are like triacylglycerols, except that the fatty acid on one end of glycerol is replaced with phosphate (Fig. 11-10, p.367). The phosphate group is often conjugated to a polar alcohol like ethanolamine (to make phosphatidylethanolamine, Fig 11-10B, p.367), serine (to make phosphatidylserine, Fig 11-7, p.366) or choline (to make phosphatidylcholine, Fig 11-6, p.366). OH CHH CH CH O C3 2 2 CH CH CH2 OHH OH OH glyerolll CH NH 3 OH CH3 HC (CH 222 CH 2HH CH3 CH OHH 3 retnolll sphngosinen tetoserone Sphingolipids: These are based on sphingosine (see figure). If a fatty acid is attached to the nitrogen of sphingosine via an amide linkage, the molecule is called a ceramide. The terminal hydroxyl group can be modified with phosphoethanolamine or phosphocholine to make sphingomyelins (found in the myelin sheath of nerve cell
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