Biochemistry 2280A Study Guide - Pyruvic Acid, Mitochondrion, Glycolysis

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By the end of this topic, you should be able to: Glycolysis takes place in the cytoplasm, producing pyruvate. We have already seen that, under anaerobic conditions, pyruvate can be fermented to lactate or ethanol. Pyruvate can also be used to make glucose when necessary. In this topic we will see a third metabolic fate of pyruvate. Under aerobic conditions, pyruvate produced by glycolysis is transported into mitochondria, where it is oxidized to form co2. The mitochondrion is an organelle with two membranes. The outer membrane has many pores embedded in it, and is freely permeable to most solutes of low molecular weight (up to about 5000 da). The inner membrane has selective permeability, meaning that ions and charged molecules can only cross it if a special path is made. The inner membrane is folded to form cristae, greatly increasing its surface area. The space enclosed by the inner membrane is called the matrix.

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