Biochemistry 2280 Topic 15.docx

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Biochemistry 2280A
Christopher Brandl

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Topic 15ATP synthesisReadings p392393 461465 468469By the end of this topic you should be able toSummarize how energy flows from reduced electron carriers to ATP in the process of oxidative phosphorylationExplain the chemiosmotic hypothesisExplain the mechanism of ATP synthase including the role of each subunit of the E coli enzymeState the number of protons that move across the inner mitochondrial membrane to synthesize and export one ATP molecule and justify that numberCalculate how much ATP can be obtained by aerobic or anaerobic metabolism of one The electron transport chain pumps protons out of the mitochondrial matrix As a result under normal conditions the proton concentration in the intermembrane space is about 10fold higher than the concentration in the matrix Furthermore excess positive charge builds up on the outer surface of the inner mitochondrial membrane because the protons are not pumped with neutralizing counterions The proton concentration gradient and the electrical potential combine to produce a protonmotive force that causes protons to flow back into the matrix if they are given the opportunity Fig 1410 p462 This force is used to generate ATP Fig 1411 p462Peter Mitchell originally proposed that ATP synthesis was driven by the flow of protons down an electrochemical gradient Although not initially accepted by bi
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