Biochemistry 3385A Study Guide - Final Guide: Cyclin D1, Lig4, Cyclin E

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 3385A
• Professor: Bonnie Deroo

Document Summary

Ct = sarcoma (mesenchymal cells, fibroblasts, adipocytes, myocytes, osteoblasts) Hematopoietic = leukemia (wbc) & lymphoma (b & t cells) Growth factors oncogene is c-sis which causes glioblastoma & fibrosarcoma. : pdgf (platelet-derived growth factor) is a mitogen; : her2/neu (human epidermal gf receptor 2) from erbb2 gene; membrane-bound tyrosine kinase; causes breast & ovarian carcinomas. : ras is a gtpase that relays signals from tyrosine kinases; mutated ras (constitutively active) found in 25% of all human tumors, especially pancreas, colon, thyroid & lung. : myc/c-myc; increases cell growth & proliferation; causes burkitt"s lymphoma, lung, breast & colon amongst others. B-cell lymphoma, melanoma, breast & prostate amongst others. P53: tf that is mutated/reduced expression in >50% of all cancers. Phosphorylation: cyclin binds inactive complex inhibitory (wee1) & activating phosphates are added by kinases inhibitory is removed via phosphatase active complex. Cdk inhibitors: divided into ink4 (bind & inhibit g1/s cdks = cdk46) &