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Therapeutic Drug Monitoring.docx

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Biochemistry 3386B
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Therapeutic Drug Monitoring PharmacokineticsADMEabsorption distribution metabolism and excretion After ingestion most drugs are first passed to the liver via the hepatic portal vein where they are first pass metabolized by the liver Bioavailability is the amount of the drug that enters circulation unmetabliozed by the liver Concentration of Drug in the extracellular fluid is proportional to the intensity of its biological effect because from extracellular fluid they can enter tissue and bind receptors Concentration in Extracellular fluid is in equilibrium with plasma concentration therefore plasma concentration is indicative of drug conc at the site of receptor action WE usually use total plasma concentration unbound and bound to estimate clinical response Elimination by the kidneys begins as soon as the drug enters the blood blood concentration rises at a rate dependent on the route of administration peaks depending on the amount of drug taken and is eliminated depending on distribution and elimination rates Dosingwith each successive dose mean concentration and rate of elimination both rise With constant oral administration rate the rate of elimination will rise until it is in
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