Biology 1001A Study Guide - Midterm Guide: Reverse Transcriptase, Congolese Rainforests, Hominidae
10 Oct 2013
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Hiv pandemic 1981 (aids: pandemic: outbreak all over the world. Sub-saharan africa is hit hard: no access to clean water easily transmitted, standard of living is a lot lower, lack of medication, lack of education/awareness, more animal interaction. Hiv=zoonosis (affects non human animals and humans) Still no cure after 32 years, why: higher mutation rate than for any other virus genetic variation in the virus itself, hiv associated with gay transmissions. Viruses are different from bacteria they are not living. Retroviruses- disobey central dogma of molecular biology: dna (replication) rna (transcription) protein (translation) Reverse transcription (no proof reading enzymes for virus) Anti-viral drugs have serious side effects- attacks your own cells as well as. Genetically variable viruses, mutations occur here virus cells. Hiv lifecycle: hijack immune cells: virion (viral particle) enters host cell, reverse transcription: injects into host cell viral dna, transcription, translation, new virions assemble and enter. Integrase splices viral dna into host dna circulation.
