Biology 1202B Study Guide - Final Guide: Dna Microarray, Tumor Suppressor Gene, Organism

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1. four most common types of cancer in canada. 2. likely factors contributing to cancer incidence in canada. Heritability, but heritability of cancer is actually quite low. 3. role of cyclin/cdk complexes in cell cycle regulation. Kinase: transfers phosphate groups (phosphorylation), a powerful way to regulate proteins (posttranslational) Cdk are only active when bound to other proteins (cyclins) (another posttranslational regulation) Once bound to cyclin cdk causes phosphorylation, releasing g1/s check point, there are different cyclin and different cdk but the mechanism is the same. 4. role of proto-oncogenes, tumor suppressor genes and oncomirs in caner a. These genes are just us, there is no such thing as a cancer gene, these are genes are required for cell cycling. Egfr- (epidermal growth factor) a protein that stimulates growth (cell division), has a receptor that recognizes egf, a signalling domain that conveys to the cell the presence of egf.

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