Study Guides (248,285)
Canada (121,461)
Biology (1,540)

Microtubules.docx

2 Pages
74 Views
Unlock Document

Department
Biology
Course
Biology 2382B
Professor
Robert Cumming
Semester
Fall

Description
Microtubules (25nm) Motor Proteins (Require Energy) Anterograde Movement of Kinesin -Tracks for transport -Allow bi-direction vesicle transport -Hollow Tube; 100’s μm long Kinesin; (+)end directed, anterograde transport, -Monomer: -αβ+Tubulin exocytosis Dimer(8nm) -2 Heavy chains; head, neck and stalk (ATPase Activity) -Polymer: Protofilament -2 Light Chains (Variable); recognize cargo -13 Protofilaments make up 1 *1 ATP = Move 16nm (2 Dimers) microtubule Kinesin 1 -conventional -Organelle transport Kinesin 5 -Head domains on each end Microtubules Assembly -Cause MT to slide past each other -GTP Bound to β of Dimer Kinesin 13 -Dimers polymerize (+) end -Just head domain -As hydrolysis occurs, instability -Uses ATP to remove dimers from the (+) end occurs and once hydrolysis Microtubule Associated Proteins Dynein; (-)end directed, Retrograde transport, (MAPs)s up to ends of endocytosis -Can alter microtubule Stability -Bundle Microtubules -Heavy Chain; head and -Can be regulated via stalk (ATPase activity) phosphorylation -Linker; attaches head to stem -Different structure can influence -Stem; interacts with dynactin hetero complex; binds cargo Microtubule Formation function; proteins pack them -Cell keeps making αβ dimers, therefore differently concentration increases MAP2 and TAU; both combine to -Hits Critical Concentration; needed to begin microtubules and stabilize polymerizing microtubules +TIPs; associated with (+)end of -Concentration of free dimers stays the same MT because new dimers are all going into polymerizing the microtubules -EBI is a type that may bring other- (+)end more dynamic molecules to tip -Provides stability and can act as -(-)end capped, stable attachment sites, and reduce catastrophe Stathmin; bind to (+) end and cause curvature and may cause hydrolysis of GTP Microtubules need something to grow off of Cilia 2-10μm Flagella 10-2000μm -Microtubules can have more than one microtubule organizing centers -sweep material across tissue, -propel cells, repulsion to move Cytoplasmic Microtubules Axonemal Microtubules beat things
More Less

Related notes for Biology 2382B

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit