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2010 Final part 1.pdf

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Western University
Biology 2382B
Michael G Mac Donald

Bio2382b Final Exam Friday April23'd2010 Code 333 1)Refsum's diseaseisasevere disorder that resultsthe accumulation ofhigh levels ofphytanic leading problems acidsand itslrnsaturatedattv acid to myelin around neryes. Normally, the phytanic acidisbroken down intheperoxisome, butin patientwith Refsum's, cr-oxidatio4does not functionand there arediflerenteasons why a-oxidation isaffected.The two most probable arelikelydue to thelack ofa key enzyme respqqsiblef,otbs!{gAkllpx4 of phytanic acid,orthe absence of afunctionalEansport p-roteiprevents theimport of theenzyme intotheperoxisome. How many of the following statementsare true? J catalase-isresent intheperoxi;ome; peroxisomes are*"Ynbror"-bound organelles; the melting pointoffattyacids decreaseY as thelength ofthechain decreasesl oleicacil isconsidered a vqsaturatedfatty acidbecause itcontains one double bond; ll'estern blot analyswould discriminatebetween a normvl person and onesufferingfrom Refsum's A) One ofthe above. B) Two of the above. rouroftheabove. D) Five ofthe above, E) None of the above. 2)Which of the followingisrequiredfor normalstriateduscle function? @ calciumpumps B) depolym erizatioofT-tubule mernbranes Q) thick filamenshortening Ef troponin hydrolysis p) spindlepoleshortening I 3)A purelipidbilayerwillnot allow molecules topass,whileadding to the bilayer wouldascribemuch more functionaand biochemicalpropertiestothe and therefore thcell.ick thebestanswers tocomplete the sentences above. A) charged; GPI links; pumps B) large; fattacids; membrane jQ) large;pumps; cytoskeleton (D) charged; proteins; membrane Y; nyarophobic; cholesterol;polar heads 4)The lipid tailsatypicalcellmembrane containboth saturated and unsaturated fattyacidsWhat would the resulbe ifalof thefattyacidsinthe membrane were tobecome saturated? N Themelting pointof thelipid bilayewould decreasU\r^J"nJ&f /) Myristicacidcould notbe present. ?-*-. 1 fc) \ t.^k-rnrvr []f (1 Stearic acid could not besent. J.i^L'- \--- fft.polarheads would fo-rmmicelles. Cx'li r'\\ !J @E) None of above. r6dc .,I d-*n'ruri tu_1+!3 U NNl' STA + (oJA/' ^n/V\t* 5)Integnin ia typeone transmembrane protein.From this weknow that: ,.' / (D t*o ,r* c) three u'/- ?,t,- ':";i D) four ( prY \ E) noneoftheabove ' c,.- c-Fos,you foundusingl yeast-trhybridaSS-ay-that: ld; Tocompletg thecharintoanAp-lnocomplexwith the c-Junrotein. Whichoneofthe followingtht(d'F)ry,b'i dimerizesnon-covalentoconvinceyour audiencethathisoccursnaturallynlivingcells? -1\, wo.ldyou haveto use eateltdse r -dd,,n,^ p,f XOYI--> enNor.rb LJq.i"t '"r,Jf,, "/cen'a"t*-llt*,,*",^,\e-: lfl&pe,^{*nr,(o}5.hurnop'}'['r "F lT)Many peoplefrom theSwedish provinceofNorrbottenhavea genetic.diseaselledO"rrrh.r'rtt67- type Itrwhich is dueoa singleutationinexol l0 oftheglucocJrebrosidasqene,leadingtoa I toleucinesubstitution.e resultsan accumulationofglucocerebrosidencertainhite "V, bloodecellshatcontributeoan enlargedlivernd spleen.Yourtaskistoselecttheproper technique I ",o/ horyitalabwould needinorderto screenapopulationofindMduals for thdisease.The best to detecthismutatedenzyme is: ic4uf -.t/JdEMSA - pi"rilraiography K- * I L c,aY;\ uil toP4GE- . --,.a.q ,{','!^"', QDt FRET analysist4FitlD.lno,;*' , qS',r,'""-ir'"v, fi ;ilit;irfraensitygradientcentritugatio"-rnsrly I r1 W-# l!)Gaucher,sdiseaseis alsoonsideredo bethemost common ofthelysosomalstorirgeiseases. Which one ofthefollowingis the bestpothesisou canthinkof thatould contributeo symptoms - *:Laryeft";;rht"d to aprobiemyitntne.iy"oro-.i th r''rL "" 'K Huoholfu ljot*-) H-Tfrt-,f.'"iT;:""?!ffi"J:#il"T;ilH;';,"^ I /" rv drffi^*,.,,,. fl. J-,gf ay;eractiveadenylylcyclaseI h'qh (AI\4f r}''*'u{ KctIh,"'"''rlp3iI 4 i' ti7) absence of COPIIvesicles€€ -r CJtq'(ontt r K'x**f jt I -r - +.:"'81ominantfweelJ"ceJtxtlf;T.,4l1lT".rt 't - l/t p 'g- f r:+t_#, J^-.yI ,l k ( 19)Which secretedrotein(s)ontainshetripeptideequenceArg-Gly-Asp? \eG D i (.ot**/ '@i"r.gri" \,r*ryr*u 1 ,, B) fibronectin :ry[* . C) lamin K( tr/ Lr)presunn t n E) all ofe above. I u, 4 ruo(eerpl ' ,/ y- {(r!,*,a r
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